{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01348 is a long non-coding RNA that is significantly downregulated in hepatocellular carcinoma (HCC) and is associated with patient survival outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Experimental data demonstrated that ectopic expression of LINC01348 markedly inhibited cell proliferation and metastasis in vitro and in vivo, whereas its knockdown produced the opposite effect."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Mechanistically, LINC01348 forms a complex with the splicing factor SF3B3, modulating the alternative splicing of EZH2 pre-mRNA. This splicing regulation, in turn, alters the activity of the JNK/c-Jun signaling pathway and affects the expression of Snail, a key factor in the metastatic cascade."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, the study revealed that C-terminal truncated HBx (Ct-HBx) downregulates LINC01348 via c-Jun signaling, thereby implicating a broader regulatory network influencing HCC metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Collectively, these findings not only underscore the critical role of LINC01348 in HCC progression but also highlight its potential as a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yang-Hsiang Lin, Meng-Han Wu, Yi-Chung Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01905-3"}], "href": "https://doi.org/10.1038/s41388-021-01905-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34140643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34140643"}]}]}]}