{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two recent studies highlight the diverse roles of long noncoding RNAs (lncRNAs) in cancer, with one study providing direct functional evidence for the oncogenic role of LINC01116 in prostate cancer (1). In this investigation, sulforaphane (SFN)—a chemopreventive compound found in cruciferous vegetables—was shown to significantly alter the expression of numerous lncRNAs in prostate cells. In particular, SFN treatment led to the transcriptional repression of LINC01116, which is typically overexpressed in several cancers. Functional assays demonstrated that reducing LINC01116 expression via siRNA knockdown or CRISPR/CAS9-mediated disruption decreased prostate cancer cell proliferation, reduced colony formation by fourfold, and up-regulated genes involved in glycolysis (GAPDH), autophagy (MAP1LC3B2), and chromatin structure (H2AFY). These results support an oncogenic function for LINC01116, suggesting that its down-regulation contributes to the anti-cancer effects of SFN (1)."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, a second study focused on immune‐related lncRNAs as prognostic indicators in colorectal cancer (CRC) (2). Although this study did not specifically characterize LINC01116, it underscored the broader clinical significance of dysregulated lncRNAs in cancer prognosis by developing a risk scoring model based on differentially expressed immune‐related lncRNAs. This work reinforces the concept that lncRNAs, such as LINC01116 in prostate cancer, play vital roles in tumor progression and may serve as valuable biomarkers for individualized treatment strategies (2).\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings emphasize that targeting specific lncRNAs like LINC01116 can modulate key cancer-related pathways and influence clinical outcomes, thereby offering promising avenues for both cancer prevention and treatment.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "  (2)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Laura M Beaver, Rachael Kuintzle, Alex Buchanan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nutr Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jnutbio.2017.01.001"}], "href": "https://doi.org/10.1016/j.jnutbio.2017.01.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28131897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28131897"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fengxia Qin, Houxi Xu, Guoli Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Prognostic Model Based on the Immune-Related lncRNAs in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.658736"}], "href": "https://doi.org/10.3389/fgene.2021.658736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33959151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33959151"}]}]}]}