{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC01352 has emerged as a multifunctional regulatory molecule with cancer‐specific roles. In lung squamous cell carcinoma, LINC01352 is part of a competitive endogenous RNA (ceRNA) network, where it interacts with miR‐2278 along with several other lncRNAs to serve as a potential diagnostic and prognostic biomarker panel."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In lung adenocarcinoma, LINC01352 has been identified among a set of 12 ferroptosis‐related lncRNAs that form a robust risk prediction model, highlighting its relevance as a prognostic indicator in this heterogeneous malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the context of HBV‐related hepatocellular carcinoma, LINC01352 functions as a tumor suppressor; its expression is markedly downregulated by the HBV X protein (HBx) via formation of a complex with estrogen receptor α. This downregulation diminishes LINC01352’s role as an endogenous sponge for miR‐135b, ultimately reducing adenomatous polyposis coli (APC) levels and triggering activation of the Wnt/β‐catenin pathway, thereby promoting tumor growth and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, broader analyses of lncRNA‐based prognostic signatures, including those incorporating LINC01352, have underscored the utility of these biomarkers in refining risk stratification in cancers such as endometrial carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Zhang, Lei Deng, Ying Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel long noncoding RNA (lncRNA) panel as biomarkers for prognosis in lung squamous cell carcinoma via competitive endogenous RNA (ceRNA) network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tcr-20-2410"}], "href": "https://doi.org/10.21037/tcr-20-2410"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35116269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35116269"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lu Lu, Le-Ping Liu, Qiang-Qiang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Ferroptosis-Related LncRNA Signature as a Novel Prognosis Model for Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.675545"}], "href": "https://doi.org/10.3389/fonc.2021.675545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34249715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34249715"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pinbo Huang, Qiaodong Xu, Yongcong Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HBx/ERα complex-mediated LINC01352 downregulation promotes HBV-related hepatocellular carcinoma via the miR-135b-APC axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-1254-z"}], "href": "https://doi.org/10.1038/s41388-020-1254-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32157216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32157216"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hong Tang, Zhixi Wu, Yuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Function Analysis of a Five-Long Noncoding RNA Prognostic Signature for Endometrial Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2019.4944"}], "href": "https://doi.org/10.1089/dna.2019.4944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31539276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31539276"}]}]}]}