{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC01354 has emerged as an important oncogenic regulator in a variety of cancers. In colorectal cancer, LINC01354 is significantly upregulated and promotes cell proliferation, migration, and epithelial‐mesenchymal transition (EMT) by enhancing the mRNA stability of β‐catenin through interaction with hnRNP‑D, thereby activating the Wnt/β‑catenin signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‐small cell lung cancer, elevated LINC01354 expression correlates with advanced TNM stage and poor prognosis, functioning in part by competitively binding to miR‑340‑5p to upregulate ATF1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In endometrial cancer, LINC01354 acts as a molecular sponge for miR‑216b to derepress the oncogene KRAS, thereby promoting tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in osteosarcoma, overexpressed LINC01354 enhances cell invasion and EMT via upregulating integrin β1, contributing to increased metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, beyond its direct mechanistic roles, LINC01354 has been identified as a component of several prognostic signatures across different tumor types, underscoring its potential value as a biomarker. It has been recognized as a methylation‐driven prognostic marker in lung adenocarcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", as part of a recurrence‐predictive model in laryngeal squamous cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and within a pyroptosis‑related lncRNA signature in gastric adenocarcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In addition, its prognostic relevance has been supported in head and neck squamous cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and thyroid carcinoma, where it is among the most significantly dysregulated lncRNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies reveal that LINC01354 exerts multifaceted oncogenic effects—ranging from modulating key signaling pathways, such as Wnt/β‑catenin and ERK, to acting as a competing endogenous RNA that regulates critical oncogenes. Its consistent upregulation and association with aggressive phenotypes across diverse cancers highlight LINC01354 as a promising candidate for both prognostic assessment and targeted therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Li, Meirong He, Wen Xu, et al. 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