{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted the diverse roles of long noncoding RNAs (lncRNAs) in regulating cell identity, differentiation, and cancer progression. For instance, one study showed that lncPRESS1 is a p53‐regulated transcript that maintains pluripotency in human embryonic stem cells by interfering with SIRT6‐mediated deacetylation at key promoters."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, other work has demonstrated that changes in physical cues such as substrate stiffness can modulate the expression of multiple lncRNAs during endoderm formation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and distinct immune‐related lncRNA signatures have been developed to predict prognosis and immunotherapy responses in bladder cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast to these lncRNAs, LINC01356 has been identified in an integrative analysis of The Cancer Genome Atlas data as one of the key prognostic stemness‐related genes in bladder urothelial carcinoma (BLCA)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Its upregulation correlates with higher mRNA expression–based stemness indices, advanced clinical stage, bone metastasis, and poorer overall survival in BLCA patients. Although the precise molecular mechanisms remain to be fully elucidated, the inclusion of LINC01356 in a predictive model—together with other genes linked to pathways such as DNA repair, MYC targets, E2F targets, mTORC1 signaling, and the unfolded protein response—suggests that it contributes to the maintenance of cancer stem cell–like properties and tumor progression.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Thus, while several lncRNAs regulate cell fate or immune responses in different contexts (1,2,4), LINC01356 appears to be a promising prognostic biomarker and potential therapeutic target specifically in the setting of bladder cancer, where its expression may reflect underlying cancer stemness and aggressive disease behavior.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Abhinav K Jain, Yuanxin Xi, Ryan McCarthy, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Control of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.aay0264"}], "href": "https://doi.org/10.1126/sciadv.aay0264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32076643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32076643"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lianghao Zhang, Longqing Li, Yonghao Zhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Immune-Related lncRNA Signature to Predict Prognosis and Immunotherapeutic Efficiency in Bladder Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.542140"}], "href": "https://doi.org/10.3389/fonc.2020.542140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33552945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33552945"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yao Kang, Xiaojun Zhu, Xijun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Validation of the Prognostic Stemness Biomarkers in Bladder Cancer Bone Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.641184"}], "href": "https://doi.org/10.3389/fonc.2021.641184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33816287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33816287"}]}]}]}