{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01358 is significantly up‐regulated in prostate cancer tissues compared to adjacent non-cancerous tissues, with even higher expression noted in metastatic cases. Elevated levels of this long noncoding RNA are correlated with postoperative biochemical relapse, suggesting its involvement in prostate cancer progression. Functional studies in DU145 prostate cancer cells demonstrate that knockdown of LINC01358 results in marked inhibition of cell proliferation and migration, supporting its role as an oncogene. These findings indicate that LINC01358 may serve as an early diagnostic biomarker and a potential target for gene therapy in prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bin Xu, Shu-Qiu Chen, Ning Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of long noncoding RNA LINC01358 in prostate cancer and its effect on the proliferation and migration of prostate cancer cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Nan Ke Xue (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29282912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29282912"}]}]}]}