{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent work has highlighted that diverse circulating noncoding RNAs (ncRNAs) can serve as reliable, noninvasive biomarkers for hepatocellular carcinoma (HCC) diagnosis and prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In this context, one long noncoding RNA—LINC01359—has been identified among the ncRNAs that are significantly upregulated in the plasma of HCC patients. LINC01359 appears to be a promising candidate biomarker because it is detectable in cell‐free RNA transcriptomes despite the presence of RNases, most likely by virtue of its interactions with RNA‐binding proteins that protect it from degradation. Consequently, beyond its utility for noninvasive HCC detection and outcome prediction, LINC01359 may also shed light on aberrant molecular signaling pathways that contribute to tumor progression. This emerging function underscores its potential dual role in clinical biomarker development and as a window into the underlying biology of HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chang Tan, Jingyi Cao, Lu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1373/clinchem.2018.301150"}], "href": "https://doi.org/10.1373/clinchem.2018.301150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30996051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30996051"}]}]}]}