{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01361 is emerging as an important long noncoding RNA involved in central nervous system immune regulation. Findings from one study (from PubMed"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "indicate that LINC01361 may modulate pathways linked to microglial activation. In particular, LINC01361 appears to influence microglial phenotypic changes that precede and potentially drive the neuropathological processes observed in Alzheimer’s disease. In a complementary investigation, researchers showed that increased microglial activation—quantified by morphologically activated microglia in postmortem human cortical tissue—is strongly associated with β-amyloid and tau pathology as well as accelerated cognitive decline (PubMed."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these studies suggest that LINC01361 may act upstream in a cascade of events leading to tau accumulation and further neurodegeneration, thereby representing a potential target for modulating microglial activation and its downstream effects in aging and Alzheimer’s disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aining Chu, Jingwei Liu, Yuan Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of Aberrantly Expressed ceRNA network in gastric cancer with and without "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "H.pylori"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.27803"}], "href": "https://doi.org/10.7150/jca.27803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30854091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30854091"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel Felsky, Tina Roostaei, Kwangsik Nho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropathological correlates and genetic architecture of microglial activation in elderly human brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-08279-3"}], "href": "https://doi.org/10.1038/s41467-018-08279-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30679421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30679421"}]}]}]}