{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01362 is a long non‐coding RNA that has been implicated in the transcriptional response to cigarette smoking. In a whole‐blood RNA sequencing study comparing current to former smokers, LINC01362 was one of several long non‐coding RNAs found to be differentially expressed, suggesting that changes in its expression may contribute to the complex regulatory effects triggered by smoking exposure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although a separate study focused on microglial activation in the aging brain and its role in Alzheimer’s disease did not explore LINC01362 directly, the emphasis on regulatory mechanisms in diverse pathological contexts underscores the potential relevance of non‐coding RNAs like LINC01362 in mediating environment‐induced molecular responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings highlight LINC01362 as a candidate molecule for further investigation into how smoking might influence immune and inflammatory pathways through the modulation of gene expression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Margaret M Parker, Robert P Chase, Andrew Lamb, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-017-0295-9"}], "href": "https://doi.org/10.1186/s12920-017-0295-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28985737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28985737"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel Felsky, Tina Roostaei, Kwangsik Nho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropathological correlates and genetic architecture of microglial activation in elderly human brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-08279-3"}], "href": "https://doi.org/10.1038/s41467-018-08279-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30679421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30679421"}]}]}]}