{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of LINC01363 Function</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n The study (1) investigated genetic determinants of weight loss response in obese subjects following low‐caloric dietary interventions. The authors identified loci near NKX6.3/MIR486 and RBSG4 that were associated with the efficiency of weight loss. Functional experiments in Drosophila melanogaster demonstrated that altering the levels of HGTX—the fly ortholog of NKX6.3—significantly affected triglyceride levels through actions in the hepatocyte‐like oenocytes, thereby implicating NKX6.3 in the regulation of lipid metabolism and weight control.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although the inquiry focuses on LINC01363, the abstract provided does not include any information regarding LINC01363 or its function. Therefore, based on the available data, there is no reported functional role for LINC01363 in the context of the described weight loss and lipid metabolic processes.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Armand Valsesia, Qiao-Ping Wang, Nele Gheldof, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-08492-8"}], "href": "https://doi.org/10.1038/s41467-019-08492-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30710084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30710084"}]}]}]}