{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as key regulators of gene expression with diverse roles in development, metabolism, and disease. Recent genome‐wide and big data analyses have identified LINC01370 as a candidate susceptibility gene associated with idiopathic osteonecrosis of the femoral head (IONFH) (1). This finding suggests that LINC01370 may contribute to the pathogenesis of IONFH by influencing molecular networks that govern bone homeostasis and vascular integrity, potentially modulating the effect of environmental risk factors such as alcohol consumption. More broadly, the discovery of LINC01370’s involvement in IONFH complements a growing body of literature demonstrating that lncRNAs regulate transcriptional and post‐transcriptional processes in a variety of tissues and disease contexts (2,3,4). Further investigations into the functional mechanisms of LINC01370 are warranted to fully elucidate its role as a potential biomarker and therapeutic target in osteonecrotic disorders."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuma Sakamoto, Takuaki Yamamoto, Nobuhiko Sugano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-14778-y"}], "href": "https://doi.org/10.1038/s41598-017-14778-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29118346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29118346"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amanda Salviano-Silva, Sara Cristina Lobo-Alves, Rodrigo Coutinho de Almeida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Noncoding RNA (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ncrna4010003"}], "href": "https://doi.org/10.3390/ncrna4010003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29657300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29657300"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maude Giroud, Marcel Scheideler "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNAs in Metabolic Organs and Energy Homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18122578"}], "href": "https://doi.org/10.3390/ijms18122578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29189723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29189723"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xu-Yun Zhao, Jiandie D Lin "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNAs: A New Regulatory Code in Metabolic Control."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Biochem Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tibs.2015.08.002"}], "href": "https://doi.org/10.1016/j.tibs.2015.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26410599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26410599"}]}]}]}