{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01391 functions as a tumor‐suppressive long noncoding RNA in multiple cancer types. In gastric cancer, LINC01391 is expressed at low levels, and its overexpression significantly impairs cancer cell proliferation, migration, invasion, and aerobic glycolysis, ultimately delaying tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, piplartine treatment induces upregulation of LINC01391, which in turn inhibits tumor cell proliferation and invasion while promoting apoptosis. Mechanistically, LINC01391 interacts with ICAT to enhance its inhibitory effect on the Wnt/β-catenin pathway, thereby suppressing tumor growth both in vitro and in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cuijuan Qian, Zhurong Xu, Luyan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01391 restrained gastric cancer aerobic glycolysis and tumorigenesis via targeting miR-12116/CMTM2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.48365"}], "href": "https://doi.org/10.7150/jca.48365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33033510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33033510"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoxi Fan, Jingjing Song, Zhongwei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/β-catenin pathway inactivation through ICAT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.06.008"}], "href": "https://doi.org/10.1016/j.canlet.2019.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31207322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31207322"}]}]}]}