{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study of tamoxifen‐treated, estrogen receptor–positive breast cancer patients (1), a panel of six long noncoding RNAs was identified to be significantly associated with distant metastasis‐free survival. Among these, LINC01399 appears to play a role as part of a predictive signature that stratifies patients into low‐ and high‐risk groups regarding metastasis and treatment outcome. While the study did not elucidate a direct mechanistic role for LINC01399, its inclusion in the six‐lncRNA signature suggests that changes in its expression, alongside those of the other five lncRNAs, may serve as a prognostic biomarker for tamoxifen sensitivity and overall disease progression."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gen Wang, Xiaosong Chen, Yue Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA Signature and Disease Outcome in Estrogen Receptor-Positive Breast Cancer Patients Treated with Tamoxifen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Breast Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4048/jbc.2018.21.e39"}], "href": "https://doi.org/10.4048/jbc.2018.21.e39"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30275856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30275856"}]}]}]}