{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01405 is a long non‐coding RNA that has emerged as a notable player in diverse disease contexts. In the setting of HER‐2–enriched breast cancer, high‐throughput transcriptome analysis identified LINC01405 among a set of dysregulated lncRNAs, with coexpression network analysis highlighting it as one of the core genes potentially involved in regulating key oncogenic pathways such as MAPK signaling, PI3K–Akt signaling, metabolic processes, cell cycle progression, and actin cytoskeleton dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In another study addressing skeletal muscle dysfunction in chronic obstructive pulmonary disease, LINC01405 was found to be among the transcripts exhibiting at least a twofold change, suggesting that its dysregulation might contribute to the molecular remodeling underlying quadriceps muscle impairment in these patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in tongue squamous cell carcinoma, LINC01405 was identified as one of several pivotal lncRNAs with aberrant expression profiles. Its potential role as a prognostic marker in TSCC underscores its importance and warrants further investigation into its mechanistic contributions to tumor pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies implicate LINC01405 in the regulation of critical signaling networks in cancer and possibly in the context of muscle dysfunction associated with chronic disease, highlighting its potential as both a biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fan Yang, Shixu Lyu, Siyang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression profile analysis of long noncoding RNA in HER-2-enriched subtype breast cancer by next-generation sequencing and bioinformatics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S97664"}], "href": "https://doi.org/10.2147/OTT.S97664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26929647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26929647"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Saffron A G Willis-Owen, Anna Thompson, Paul R Kemp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-29789-6"}], "href": "https://doi.org/10.1038/s41598-018-29789-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30111857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30111857"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mi Zhang, Zexi Chen, Sihui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of Differentially Expressed Long Non-coding RNAs and the Associated TF-mRNA Network in Tongue Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.01421"}], "href": "https://doi.org/10.3389/fonc.2020.01421"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32923393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32923393"}]}]}]}