{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01410 is increasingly recognized as an oncogenic long non‐coding RNA that is dysregulated in a broad spectrum of human malignancies. Its upregulation has been documented in cholangiocarcinoma, endometrial cancer, glioma, glioblastoma, osteosarcoma, neuroblastoma, colorectal cancer, colon cancer, bladder cancer, esophageal squamous cell carcinoma, gallbladder cancer, cervical cancer, and gastric cancer, where elevated expression is frequently associated with advanced disease features and poor prognosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "16"}]}, {"type": "t", "text": " Functionally, LINC01410 predominantly acts as a competing endogenous RNA (ceRNA) that sponges various microRNAs—including miR-124-3p, miR-23c, miR-506-3p, miR-370-3p, miR-122-5p, miR-3128, miR-497-5p, miR-4319, miR-545-3p, miR-532-5p, and miR-2467-3p—to de-repress their target messenger RNAs. This molecular decoy mechanism consequently leads to the upregulation of oncogenic effectors such as SMAD5, CHD7, NOTCH2, components of the PTEN/AKT pathway, NDRG3, WEE1, HMGA2, Snail1, PKM2, HK2, VOPP1, and sustained NF-κB signaling via NCF2, among others, thereby promoting tumor cell proliferation, migration, invasion, epithelial-mesenchymal transition, metastasis, and, in some contexts, resistance to therapy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}, {"type": "fg_fs", "start_ref": "9", "end_ref": "12"}, {"type": "fg_f", "ref": "17"}, {"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": " In addition, LINC01410 can be encapsulated in exosomes to mediate intercellular communication within the tumor microenvironment, further contributing to metastasis and the epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Although one study in systemic lupus erythematosus did not observe significant alteration of LINC01410 expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", the overwhelming evidence across cancer models underscores its critical role as a promoter of tumor progression. Collectively, these findings suggest that LINC01410 represents a potential diagnostic biomarker and a promising therapeutic target in multiple cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Jiang, Chunlin Wang, Yunxie Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01410 promotes cell proliferation and migration of cholangiocarcinoma through modulating miR-124-3p/SMAD5 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3162"}], "href": "https://doi.org/10.1002/jgm.3162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31951299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31951299"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ming Lu, Ning Ding, Shichao Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01410/miR-23c/CHD7 functions as a ceRNA network to affect the prognosis of patients with endometrial cancer and strengthen the malignant properties of endometrial cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-020-03723-9"}], "href": "https://doi.org/10.1007/s11010-020-03723-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32314193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32314193"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xinli Zhao, Fazheng Shen, Bo Yang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01410 Induced by MYC Accelerates Glioma Progression via Sponging miR-506-3p and Modulating NOTCH2 Expression to Motivate Notch Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Neurobiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10571-021-01042-1"}], "href": "https://doi.org/10.1007/s10571-021-01042-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33712887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33712887"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tingkai Fu, Yunxue Yang, Zhenxin Mu, et al. 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