{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01411 is a long non‐coding RNA whose dysregulation has been detected in diverse pathological contexts. In osteoarthritis, LINC01411 was significantly upregulated in lesioned subchondral bone compared to intact bone (fold change = 7.39, with high statistical significance), suggesting a potential role in the altered gene‐regulatory networks underlying joint degeneration (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cervical cancer, LINC01411 emerged as a member of an eight‐lncRNA prognostic signature defined by subtype‐specific copy number variation patterns; its altered expression contributes to a molecular network involved in tumor metabolism, immunity, and key signaling pathways such as p53 and cAMP, correlating with poorer patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, a genome‐wide association study investigating cocaine use disorder identified a single nucleotide polymorphism within LINC01411 that was significantly associated with heavy cocaine use in African American individuals, indicating that genetic variation in this lncRNA may modulate susceptibility to substance use disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Although a separate study designed to identify prostate cancer–specific lncRNAs did not report on LINC01411"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", the collective evidence supports a multifaceted role for LINC01411 in contributing to disease‐specific regulatory mechanisms across musculoskeletal, oncologic, and neuropsychiatric disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Margo Tuerlings, Marcella van Hoolwerff, Jessica M van Bokkum, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Rheumatology (Oxford) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/rheumatology/keab826"}], "href": "https://doi.org/10.1093/rheumatology/keab826"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34730803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34730803"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qihang Zhong, Minzhen Lu, Wanqiong Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Eight-lncRNA signature of cervical cancer were identified by integrating DNA methylation, copy number variation and transcriptome data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-021-02705-9"}], "href": "https://doi.org/10.1186/s12967-021-02705-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33557879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33557879"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiangwen Sun, Henry R. Kranzler, Joel Gelernter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatry Neurosci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1503/jpn.180098"}], "href": "https://doi.org/10.1503/jpn.180098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31490055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31490055"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Cheng-Cheng Hu, Ping Gan, Rui-Ying Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of prostate cancer LncRNAs by RNA-Seq."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2014.15.21.9439"}], "href": "https://doi.org/10.7314/apjcp.2014.15.21.9439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25422238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25422238"}]}]}]}