{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A whole‐genome sequencing study of Alzheimer’s disease in a Chinese population identified disease‐associated variants in non‐coding regions, potentially including loci near LINC01413."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in colorectal cancer, LINC01413 has been functionally characterized as a positive regulator of tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Elevated levels of LINC01413 in colorectal cancer tissues correlate strongly with adverse clinicopathological features such as increased tumor size, advanced stage, lymph node involvement, and distant metastasis. Functional studies demonstrate that LINC01413 promotes key malignant processes including cellular proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT). Mechanistically, LINC01413 binds to hnRNP‑K, a well‐known RNA‐binding protein, which in turn facilitates the nuclear translocation of YAP1 and TAZ1. This translocation ultimately upregulates the expression of ZEB1, a critical transcription factor that drives EMT and tumor progression. Collectively, these results position LINC01413 as an important molecular player with potential implications in both neurodegenerative contexts and, more clearly, in colorectal cancer progression, suggesting it could be a promising target for future therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaopu Zhou, Yu Chen, Kin Y Mok, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1715554115"}], "href": "https://doi.org/10.1073/pnas.1715554115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29432188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29432188"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ling Ji, Xiang Li, Zhenhua Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01413/hnRNP-K/ZEB1 Axis Accelerates Cell Proliferation and EMT in Colorectal Cancer via Inducing YAP1/TAZ1 Translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2019.11.027"}], "href": "https://doi.org/10.1016/j.omtn.2019.11.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31927328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31927328"}]}]}]}