{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01426 is an oncogenic long noncoding RNA that is aberrantly upregulated in several cancer types, including lung adenocarcinoma, glioma, clear cell renal cell carcinoma, and glioblastoma. In lung adenocarcinoma, LINC01426 not only promotes cell proliferation, migration, epithelial–mesenchymal transition, and stemness but also activates the hedgehog signaling pathway by recruiting USP22 to stabilize the SHH protein and by modulating the miR‐125a-5p/CSNK2A1 axis, with its overexpression correlating with advanced tumor stage and poorer overall survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In glioma, elevated LINC01426 expression has been linked to enhanced proliferation, migration, and invasion while its knockdown induces apoptosis, partly through modulation of the PI3K/Akt signaling pathway, thereby serving as an independent prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In clear cell renal cell carcinoma, LINC01426 exerts its tumor‐promoting effects by upregulating FOXM1 through a regulatory network that involves sponging miR-423-5p and engaging with IGF2BP1/CTBP1/HDAC2, further aggravating tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In glioblastoma, LINC01426 facilitates tumor cell proliferation and growth by functioning as a molecular sponge for miR345-3p, leading to an increase in the oncogenic protein VAMP8."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n LINC01426 has also been incorporated into prognostic risk models for osteosarcoma and squamous cell lung carcinoma, and it is highlighted in reviews on noncoding RNAs in human diseases such as HIV/AIDS, underscoring its emerging value as both a biomarker and a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies reveal that LINC01426 contributes to malignant progression across multiple cancers by modulating key signaling pathways and miRNA networks, emphasizing its importance in tumor biology and its promise as a prognostic indicator and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoli Liu, Zuwei Yin, Linping Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03435-y"}], "href": "https://doi.org/10.1038/s41419-021-03435-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33568633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33568633"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoling Zhu, Jianguo Zhao, Jun Xu "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01426 promotes the progression of lung adenocarcinoma via regulating miRNA-125a-5p/ casein kinase 2 alpha 1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2044251"}], "href": "https://doi.org/10.1080/21655979.2022.2044251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35266446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35266446"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoyang Han, Hua Jiang, Jianni Qi, et al. 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