{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent efforts in characterizing long non‐coding RNAs (lncRNAs) have demonstrated their diverse roles in gene regulation and disease. A novel computational tool, PLAIDOH, was developed to integrate multiple layers of “omics” data and predict functional interactions between lncRNAs, coding genes, and proteins in lymphoma, thereby expediting the discovery and validation of lncRNA functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate study, LINC01431 was identified as a host restriction factor for hepatitis B virus (HBV) transcription. Mechanistically, LINC01431 competitively binds to the type I protein arginine methyltransferase (PRMT1), preventing its HBx-mediated ubiquitination and degradation. As a result, enhanced PRMT1 occupancy on the covalently closed circular DNA (cccDNA) of HBV increases H4R3me2a modifications and decreases acetylation of histones bound to cccDNA, thereby repressing viral transcription. Moreover, HBV counteracts this restriction by transcriptionally repressing LINC01431 via HBx-mediated inhibition of the transcription factor Zinc fingers and homeoboxes 2 (ZHX2), establishing a feedback loop that sustains viral replication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sarah C Pyfrom, Hong Luo, Jacqueline E Payton "}, {"type": "b", "children": [{"type": "t", "text": "PLAIDOH: a novel method for functional prediction of long non-coding RNAs identifies cancer-specific LncRNA activities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-019-5497-4"}], "href": "https://doi.org/10.1186/s12864-019-5497-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30767760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30767760"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Sun, Yan Teng, Liyuan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202103135"}], "href": "https://doi.org/10.1002/advs.202103135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35398991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35398991"}]}]}]}