{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01433 is emerging as an oncogenic long noncoding RNA implicated in the progression of several human cancers. In hepatocellular carcinoma, upregulation of LINC01433 promotes cell proliferation, colony formation, and invasion while suppressing apoptosis, at least in part through its sponging of miR‑1301 and subsequent modulation of STAT3 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In nasopharyngeal carcinoma, LINC01433 similarly facilitates proliferation, migration, and invasion by negatively regulating miR‑506‑3p, which can attenuate these malignant behaviors when restored."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In esophageal squamous cell carcinoma, elevated LINC01433 levels are associated with increased tumor size and lymph node metastasis; mechanistically, LINC01433 promotes malignant progression via downregulation of miR‑1301, further underscoring its role as a positive regulator of tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In non‑small cell lung cancer, one study demonstrated that LINC01433 is significantly overexpressed in tumor tissues and its upregulation enhances proliferation, migration, invasion, and epithelial‑to‑mesenchymal transition, suggesting an oncogene‑like effect"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "; however, another investigation in an Iranian patient cohort reported no significant difference in LINC01433 expression between tumor and non‑tumor tissues, indicating that its contribution to lung cancer may be influenced by population‑specific factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In gastric cancer, LINC01433 is also notably upregulated and correlates with poor prognosis. Functionally, it enhances cell proliferation, migration, invasion, and chemoresistance by stabilizing the oncoprotein YAP through a feedback loop that involves the deubiquitinase USP9X."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these studies suggest that LINC01433 largely acts as an oncogene across different tumor types by modulating microRNA networks and signaling pathways, thereby representing a promising potential biomarker and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haijin Huang, Yan-Zhi Bu, Xiao-Yu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01433 promotes hepatocellular carcinoma progression via modulating the miR-1301/STAT3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27366"}], "href": "https://doi.org/10.1002/jcp.27366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30317567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30317567"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mingguang Zhou, Zhihuai Dong, Sunhong Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01433 targets miR-506-3p to promote the biological progress of nasopharyngeal carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Arch Otorhinolaryngol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00405-021-06607-w"}], "href": "https://doi.org/10.1007/s00405-021-06607-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33479848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33479848"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "L Zheng, Y-T Liu, C-P Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA linc01433 promotes tumorigenesis and progression in esophageal squamous cell carcinoma by sponging miR-1301."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202005_21167"}], "href": "https://doi.org/10.26355/eurrev_202005_21167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32432741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32432741"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Banglun Qian, Xiang Wang, Chao Mao, et al. 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