{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01436 is a long noncoding RNA that has emerged as a critical oncogenic regulator in several cancer types, including non‐small cell lung cancer (NSCLC), gastric cancer (GC), and colorectal cancer (CRC). In NSCLC, LINC01436 is up‐regulated under hypoxic conditions that relieve E2F6‐mediated repression, allowing it to function as a proto‐oncogene. By acting as a molecular sponge for miR‑30a‑3p, LINC01436 de‐represses EPAS1 and thereby promotes lung cancer cell growth, migration, and invasion both in vitro and in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In GC, high levels of LINC01436 are associated with unfavorable clinical outcomes. Functional studies demonstrate that LINC01436 overexpression enhances cell proliferation, metastasis, and even radioresistance. Mechanistically, LINC01436 acts as a competing endogenous RNA by sponging tumor suppressor microRNAs—including miR‑585‑3p, miR‑513a‑5p, and miR‑585—which in turn leads to increased expression of oncogenic targets such as MAPK1, APE1, and FBOX11. Moreover, LINC01436 contributes to the epigenetic silencing of miR‑585‑3p via EZH2‐mediated trimethylation of histone H3 lysine 27 on its promoter."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In CRC, LINC01436 is also overexpressed and is linked to poor overall survival. Its oncogenic role in colorectal cancer is mediated in part by suppression of miR‑466 maturation, which leads to enhanced cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies indicate that LINC01436 functions as an oncogenic long noncoding RNA across multiple tumor types by modulating the activity of tumor suppressor microRNAs and, thereby, deregulating key oncogenic pathways.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuai Yuan, Ying Xiang, Guilu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-sensitive LINC01436 is regulated by E2F6 and acts as an oncogene by targeting miR-30a-3p in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12437"}], "href": "https://doi.org/10.1002/1878-0261.12437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30614188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30614188"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yongpan Xu, Ming Dong, Jiehong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01436 Inhibited miR-585-3p Expression and Upregulated MAPK1 Expression to Promote Gastric Cancer Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-020-06487-w"}], "href": "https://doi.org/10.1007/s10620-020-06487-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32820394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32820394"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ming-Dian Lu, Dong Liu, Yong-Xiang Li "}, {"type": "b", "children": [{"type": "t", "text": "LINC01436 Promotes the Progression of Gastric Cancer via Regulating miR-513a-5p/APE1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S257747"}], "href": "https://doi.org/10.2147/OTT.S257747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33116638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33116638"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ying Zhang, Guangyong Yang, Xiaogu He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01436, regulating miR-585 and FBXO11, is an oncogenic lncRNA in the progression of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11287"}], "href": "https://doi.org/10.1002/cbin.11287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31829474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31829474"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hong Li, Wei Dong, Jie Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC 01436 is overexpressed in colorectal cancer and promotes cancer cell proliferation by suppressing tumor-suppressive miR-466 maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "In Vitro Cell Dev Biol Anim (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11626-021-00642-x"}], "href": "https://doi.org/10.1007/s11626-021-00642-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35171402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35171402"}]}]}]}