{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLINC01441 – also referred to in one study as lncKdm2b – has been identified as a key regulator in the maintenance of intestinal group 3 innate lymphoid cells (ILC3s). In this context, high expression of this long noncoding RNA sustains ILC3 numbers and their effector functions by promoting cellular proliferation. Mechanistically, LINC01441 facilitates the transcriptional activation of Zfp292 by recruiting the chromatin organizer Satb1 and the nuclear remodeling factor (NURF) complex onto the Zfp292 promoter. Disruption of LINC01441 function leads to impaired ILC3 maintenance and increased susceptibility to bacterial infections."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate investigation focused on endocrine regulation, researchers developed a fluorescence-based quantitative reverse transcriptase polymerase chain reaction assay to determine mRNA copy numbers of growth hormone (GH) and several transcription factors (including Pit-1, Prop-1, and Zn-16) in pituitary tissues of various mouse models. Although this study did not directly address LINC01441, the precise quantification of transcription factor transcripts in relation to GH mRNA abundance provides a framework for understanding complex gene regulatory networks across different biological systems, which may offer parallels to the transcriptional regulation mechanisms observed in ILC3s."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Benyu Liu, Buqing Ye, Liuliu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3712"}], "href": "https://doi.org/10.1038/ni.3712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28319097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28319097"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Patrick W Wojtkiewicz, Carol J Phelps, David L Hurley "}, {"type": "b", "children": [{"type": "t", "text": "Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1385/ENDO:18:1:67"}], "href": "https://doi.org/10.1385/ENDO:18:1:67"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12166626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12166626"}]}]}]}