{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01446 is a long non‐coding RNA of 3484 bases located at chromosome 7p12.1 that appears to function as an oncogenic regulator in multiple cancer types. In gastric cancer, LINC01446 is markedly upregulated in tumor tissues and its high expression is associated with poor patient survival. Functionally, it promotes cell proliferation and metastasis by interacting with the histone demethylase LSD1; this interaction facilitates the recruitment of LSD1 to the promoter of RASD1, leading to the transcriptional repression of this tumor‐suppressor gene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In glioblastoma, LINC01446 is also overexpressed and correlates with adverse clinical outcomes. Mechanistic studies reveal that LINC01446 acts as a competing endogenous RNA by sponging miR‑489‑3p, thereby relieving the inhibition on TPT1. The resultant upregulation of TPT1 contributes to enhanced cell proliferation, accelerated cell-cycle progression, and increased invasive capabilities, with in vivo models further supporting its tumor‐promoting role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n These findings indicate that LINC01446 supports tumorigenesis via distinct regulatory mechanisms—either by modulating epigenetic repression of tumor suppressors or by sequestering tumor‐suppressive microRNAs—highlighting its potential as a therapeutic target in cancer treatment.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yifan Lian, Changsheng Yan, Yikai Lian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2729-0"}], "href": "https://doi.org/10.1038/s41419-020-2729-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32651355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32651355"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li Zhang, Qin Wang, Fei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01446 promotes glioblastoma progression by modulating miR-489-3p/TPT1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.07.067"}], "href": "https://doi.org/10.1016/j.bbrc.2018.07.067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30029885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30029885"}]}]}]}