{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations have highlighted the potential clinical significance of the long noncoding RNA LINC01447 in cancer. In lung adenocarcinoma, LINC01447 was identified as one of six differentially expressed lncRNAs that are significantly correlated with patient prognosis. It is proposed to act as a competitive endogenous RNA (ceRNA) by interacting with microRNAs, thereby modulating the expression of target mRNAs involved in tumor progression and offering promise as both a diagnostic and prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in hepatocellular carcinoma, LINC01447 was incorporated into a lncRNA-based risk scoring system developed to predict recurrence-free survival in tumor-positive patients. This inclusion supports the notion that aberrant expression of LINC01447 may contribute to tumorigenesis through mechanisms possibly associated with cell cycle regulation or other oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that LINC01447 may play a regulatory role in cancer progression via ceRNA-mediated networks and hold potential as a prognostic marker in both lung adenocarcinoma and hepatocellular carcinoma.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yimeng Cui, Yaowen Cui, Ruixue Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Differentially Expressed and Prognostic lncRNAs for the Construction of ceRNA Networks in Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/2659550"}], "href": "https://doi.org/10.1155/2021/2659550"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34987577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34987577"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Siyao Wu, Yayan Deng, Yue Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA Expression-Based Risk Scoring System Can Predict Survival of Tumor-Positive Patients with Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31557/APJCP.2021.22.12.3741"}], "href": "https://doi.org/10.31557/APJCP.2021.22.12.3741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34967552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34967552"}]}]}]}