{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of LINC01451 Function</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n LINC01451 is a long non-coding RNA that is upregulated in bladder cancer tissues and plays a critical role in driving cancer progression. Functional studies demonstrated that increased expression of LINC01451 enhances cellular proliferation, invasion, and metastasis. Mechanistically, LINC01451 directly interacts with the proteins LIN28A and LIN28B, which in turn facilitates the activation of the TGF-β/Smad signaling pathway. This activation promotes epithelial-mesenchymal transition (EMT), an essential process that contributes to the aggressive behavior of bladder cancer. These findings suggest that LINC01451 may function as a promising prognostic biomarker and a novel therapeutic target in bladder cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Heng Shi, Jinbo Xie, Keyi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01451 drives epithelial-mesenchymal transition and progression in bladder cancer cells via LIN28/TGF-β/Smad pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2021.109932"}], "href": "https://doi.org/10.1016/j.cellsig.2021.109932"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33516780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33516780"}]}]}]}