{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that the long non‐coding RNA (lncRNA) LINC01468 plays multifaceted roles in tumorigenesis across different cancer types. In endometrial cancer, LINC01468 is expressed at lower levels in tumor tissues compared to non‐malignant endometrium, and its expression in cancer‐free individuals is positively correlated with body mass index. These findings suggest that adequate expression of LINC01468 may exert a protective effect against the development of endometrial cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in lung adenocarcinoma LINC01468 is upregulated and transcriptionally activated by SIX5. Elevated LINC01468 levels enhance cellular proliferation, migration, and invasion by recruiting SERBP1 to stabilize SERPINE1 mRNA and by interacting with USP5 to modulate PAI1 protein ubiquitination, collectively promoting an oncogenic phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, in bladder urothelial carcinoma, LINC01468 has been identified as a component of a six-lncRNA prognostic signature associated with tumor progression and metastasis, indicating its potential utility as an independent prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these results underscore the context-dependent function of LINC01468, acting as a putative tumor suppressor in endometrial cancer while serving oncogenic roles in lung adenocarcinoma and potentially contributing to cancer progression in bladder urothelial carcinoma.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jan Bieńkiewicz, Hanna Romanowicz, Bożena Szymańska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-022-09426-2"}], "href": "https://doi.org/10.1186/s12885-022-09426-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35351056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35351056"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuan Yuan, Danyang Zhou, Feifei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-04717-9"}], "href": "https://doi.org/10.1038/s41419-022-04717-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35387981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35387981"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xin Gao, Shufang Zhang, Yinyi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of a novel six-long noncoding RNA signature predicting survival of patients with bladder urothelial carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29285"}], "href": "https://doi.org/10.1002/jcb.29285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31338862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31338862"}]}]}]}