{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study investigating osteoblast dysfunction in multiple myeloma (MM) bone disease, the long non‐coding RNA LINC01473 was found to be significantly upregulated in osteoblasts from patients with MM compared to healthy controls (1). Notably, LINC01473 exhibited a co-expression pattern with the protein-coding gene CD74, which was also upregulated in the patient group. Furthermore, LINC01473 expression demonstrated a negative correlation with serum levels of interleukin-2 and tumor necrosis factor α, suggesting a potential immunomodulatory role that could contribute to MM immune escape. These findings imply that aberrant expression of LINC01473 may not only be instrumental in the imbalance between bone formation and resorption but could also serve as a promising target for future research aimed at addressing both bone pathology and immune dysregulation in MM (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fengping Peng, Siyang Yan, Hui Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles of LINC01473 and CD74 in osteoblasts in multiple myeloma bone disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Investig Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jim-2021-002192"}], "href": "https://doi.org/10.1136/jim-2021-002192"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35145037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35145037"}]}]}]}