{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Emerging studies investigating long non‐coding RNAs (lncRNAs) in cancer have highlighted diverse roles in RNA processing, transcriptional regulation, and even potential micropeptide production."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In a recent investigation of the transcriptome in gynecologic malignancies, analysis of long intergenic non‐coding RNAs (lincRNAs) in endometrial cancer revealed that LINC01480 is uniquely upregulated in malignant endometrium in comparison with adjacent normal tissue, and its expression distinguishes endometrial tumors from ovarian and cervical cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Notably, LINC01480 possesses features indicative of a coding potential for a micropeptide, suggesting that beyond serving as a highly specific biomarker, it may have a functional role in modulating oncogenic pathways and the tumor microenvironment. This multifaceted functionality positions LINC01480 as a promising candidate for further mechanistic studies and potential clinical applications in early detection and targeted therapy of endometrial cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alison D Tang, Cameron M Soulette, Marijke J van Baren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-15171-6"}], "href": "https://doi.org/10.1038/s41467-020-15171-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32188845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32188845"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yasmine Zerdoumi, Raphaël Lanos, Sabine Raad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Germline TP53 mutations result into a constitutive defect of p53 DNA binding and transcriptional response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx106"}], "href": "https://doi.org/10.1093/hmg/ddx106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28369373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28369373"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cristina Vallone, Giuliano Rigon, Caterina Gulia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-Coding RNAs and Endometrial Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes9040187"}], "href": "https://doi.org/10.3390/genes9040187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29596364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29596364"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shaoyun Chen, Hairong Liang, Gonghua Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differently expressed long noncoding RNAs and mRNAs in TK6 cells exposed to low dose hydroquinone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.21481"}], "href": "https://doi.org/10.18632/oncotarget.21481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29221148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29221148"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bei Jun Chen, Frances L Byrne, Konii Takenaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2017.10.006"}], "href": "https://doi.org/10.1016/j.ygyno.2017.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29050779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29050779"}]}]}]}