{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations into the roles of long non‐coding RNAs in human disease and development have implicated several novel loci. In one study focused on mammographic density—a strong, heritable intermediate phenotype of breast cancer—a genome‐wide analysis identified three novel genetic loci that contribute to the variation in volumetric mammographic density (1). Although the detailed mechanistic role was not fully elucidated in that study, emerging evidence suggests that one of these novel loci, LINC01483, may function as a regulatory non‐coding RNA that influences breast tissue composition. In this context, LINC01483 is hypothesized to affect the genetic architecture underlying mammographic density, thereby modulating breast cancer risk.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, another study investigating the transcriptomic landscape of the human cumulus–oocyte complex in the setting of assisted reproductive technologies examined a broad panel of long non‐coding RNAs that are highly expressed either in metaphase II oocytes or in cumulus cells (2). This work identified lncRNAs involved in chromatin remodeling, maintenance of pluripotency, early embryonic development, apoptosis, and extracellular matrix functions. Notably, LINC01483 was not among the lncRNAs highlighted in the cumulus or oocyte profiles, suggesting that its expression and function may be context‐specific and more closely related to the biology of breast tissue rather than to the regulation of oocyte–cumulus cell interactions.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, current evidence indicates that LINC01483 may play a role in regulating mammographic density and, by extension, breast cancer susceptibility (1), while it appears not to be directly involved in the transcriptomic network governing the cumulus–oocyte dialogue in assisted reproduction (2).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "  (2)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Judith S Brand, Keith Humphreys, Jingmei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common genetic variation and novel loci associated with volumetric mammographic density."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13058-018-0954-6"}], "href": "https://doi.org/10.1186/s13058-018-0954-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29665850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29665850"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Julien Bouckenheimer, Patricia Fauque, Charles-Henri Lecellier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential long non-coding RNA expression profiles in human oocytes and cumulus cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-20727-0"}], "href": "https://doi.org/10.1038/s41598-018-20727-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29396444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29396444"}]}]}]}