{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The long noncoding RNA (lncRNA) LINC01485 has emerged as an important regulator in cancer biology. In gastric cancer, LINC01485 is notably upregulated and functions as an oncogene by promoting tumor cell proliferation, migration, and invasion. Mechanistically, LINC01485 localizes to the cytoplasm where it competes with the ubiquitin ligase c-Cbl for binding to the phosphorylated Tyr1045 residue of the epidermal growth factor receptor (EGFR). This competitive binding interferes with c-Cbl–mediated ubiquitination and degradation of EGFR, thereby stabilizing the receptor and enhancing activation of the downstream Akt signaling pathway, which in turn supports tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal cancer, LINC01485 is similarly found to be upregulated in tumor tissues compared to adjacent normal tissues. Its elevated expression is strongly associated with advanced clinical stage, lymph node metastasis, and distant metastasis. Moreover, LINC01485 shows high diagnostic sensitivity and specificity in differentiating colorectal cancer patients from healthy controls and has been incorporated into prognostic prediction models for overall survival, underscoring its potential as a clinically valuable biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight LINC01485 as a critical oncogenic lncRNA that modulates receptor signaling pathways in gastric cancer and serves as an important diagnostic and prognostic marker in colorectal cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianping Zhou, Lulu Wu, Weiling Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC01485 Promotes Tumor Growth and Migration via Inhibiting EGFR Ubiquitination and Activating EGFR/Akt Signaling in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S257151"}], "href": "https://doi.org/10.2147/OTT.S257151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32904620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32904620"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zuojian Hu, Junrong Wu, Shaolin Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic value of long noncoding RNA LINC01485 in patients with colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Biochem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinbiochem.2022.01.003"}], "href": "https://doi.org/10.1016/j.clinbiochem.2022.01.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35033545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35033545"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiao Huang, Wei Cai, Wenliang Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of key lncRNAs as prognostic prediction models for colorectal cancer based on LASSO."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2020)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32355515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32355515"}]}]}]}