{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have begun to unravel the diverse roles of non‐coding RNAs in complex diseases. In a genome‐wide association analysis focusing on stroke, multiple novel risk loci were identified; however, this study did not specifically assign a role to LINC01492 in stroke pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, an investigation into preeclampsia (PE) has demonstrated that LINC01492 is upregulated in placental tissues from affected individuals. Here, LINC01492 forms part of a competing endogenous RNA (ceRNA) network alongside hsa_circ_0088196 and miR‑100‑5p. The upregulation of LINC01492 correlates with decreased miR‑100‑5p levels, which in turn is associated with increased expression of leukemia inhibitory factor (LIF) and activation of the jak‑stat signaling pathway—a cascade implicated in the progression of PE."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings suggest that while LINC01492 has not been directly implicated in stroke, it may contribute to disease progression in preeclampsia by acting as a molecular sponge for miR‑100‑5p, thereby relieving suppression of downstream targets such as LIF.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rainer Malik, Ganesh Chauhan, Matthew Traylor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41588-018-0058-3"}], "href": "https://doi.org/10.1038/s41588-018-0058-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29531354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29531354"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Siwei Liu, Xie Xie, Huajiang Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Key circRNAs/lncRNAs/miRNAs/mRNAs and Pathways in Preeclampsia Using Bioinformatics Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.912801"}], "href": "https://doi.org/10.12659/MSM.912801"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30833538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30833538"}]}]}]}