{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01494, an emerging long noncoding RNA, is significantly upregulated in glioma and its high expression is associated with a poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional analyses revealed that silencing LINC01494 dramatically inhibited glioma cell proliferation, cell cycle progression, migration, and invasion, indicating its pivotal role in tumor progression. Mechanistically, LINC01494 acts as a competing endogenous RNA by binding to and suppressing miR-122-5p, which in turn relieves the inhibitory effect on CCNG1, ultimately promoting tumor development. Rescue experiments further confirmed that the LINC01494/miR-122-5p/CCNG1 signaling axis is critical in modulating glioma malignancy. Overall, these findings suggest that LINC01494 may serve as a potential biomarker and therapeutic target in glioma.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chang Li, Guozhang Hu, Bo Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA LINC01494 Promotes Proliferation, Migration And Invasion In Glioma Through miR-122-5p/CCNG1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S213345"}], "href": "https://doi.org/10.2147/OTT.S213345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31571916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31571916"}]}]}]}