{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01496 appears to be a regulatory long noncoding RNA implicated in diverse disease contexts. In one study of prostate cancer in men of African ancestry, a risk‐associated variant was identified at 13q34 located immediately 3′ of a long noncoding RNA – most likely LINC01496 – and 5′ of the IRS2 gene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " This positional relationship suggests that LINC01496 may play a role in modulating IRS2 expression or related signaling pathways that contribute to prostate cancer susceptibility. In a separate investigation into the host response to infection, deregulation of numerous lncRNAs in peripheral blood mononuclear cells was observed in patients with multidrug‐resistant tuberculosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although this study did not specifically highlight LINC01496 by name, the involvement of lncRNAs in immune regulation raises the possibility that LINC01496 could be among those transcripts modulating immune responses during infection. Collectively, these findings indicate that LINC01496 may be involved in both oncogenic processes—potentially through influencing nearby gene expression in prostate tissues—and in mediating immune signaling pathways in the context of infectious disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David V Conti, Kan Wang, Xin Sheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/djx084"}], "href": "https://doi.org/10.1093/jnci/djx084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29117387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29117387"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong Yan, Rufeng Xu, Xiangrong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying differentially expressed long non-coding RNAs in PBMCs in response to the infection of multidrug-resistant tuberculosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Drug Resist (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IDR.S154255"}], "href": "https://doi.org/10.2147/IDR.S154255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30034244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30034244"}]}]}]}