{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of LINC01497 Function in ESCC Prognosis</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a study focused on esophageal squamous cell carcinoma (ESCC), an eight‐lncRNA prognostic signature was identified that includes LINC01497 along with AP000487, AC011997, LINC01592, LINC01711, FENDRR, AC087045, and AC137770 (1). Within this signature, LINC01497 contributes as one of the key long non‐coding RNA components whose expression levels help differentiate patient subgroups with significantly different overall survival outcomes. Although the precise molecular mechanism of LINC01497 was not detailed within the study, its inclusion in the prognostic model—developed using methods such as univariate and multivariate Cox regression, the least absolute shrinkage and selection operator (LASSO), and validated across GEO and TCGA datasets—underscores its potential role as a predictive biomarker for ESCC aggressiveness and patient prognosis (1). This finding supports the notion that profiling specific lncRNAs like LINC01497 can provide practical and reliable tools for prognostic evaluation in ESCC."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenli Li, Jun Liu, Hetong Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a nomogram based on long non-coding RNA to improve prognosis prediction of esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102697"}], "href": "https://doi.org/10.18632/aging.102697"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31978896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31978896"}]}]}]}