{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A recent case–control study evaluated 88 single nucleotide polymorphisms (SNPs) linked to colorectal cancer (CRC) risk in first‐degree relatives of CRC patients versus controls. One of the most significant findings was related to a SNP within the long noncoding RNA LINC01500. Specifically, the rs17094983G>A variant in LINC01500 was associated with a lower risk of CRC (odds ratio = 0.72), suggesting that allelic differences in LINC01500 might confer a protective effect. Although the study focused on genotype distribution rather than elucidating a detailed biological mechanism, this association implies that LINC01500 may modulate genetic susceptibility to CRC in familial cases and could potentially serve as a biomarker for identifying individuals who might benefit from enhanced surveillance and tailored screening programs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carla J Gargallo-Puyuelo, Ángel Lanas, Patricia Carrera-Lasfuentes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Familial Colorectal Cancer and Genetic Susceptibility: Colorectal Risk Variants in First-Degree Relatives of Patients With Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Gastroenterol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14309/ctg.0000000000000301"}], "href": "https://doi.org/10.14309/ctg.0000000000000301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33534415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33534415"}]}]}]}