{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01503 is emerging as a critical oncogenic long non‐coding RNA whose expression is aberrantly upregulated in a wide spectrum of malignancies—including esophageal and head and neck squamous cell carcinomas, gastric cancer, nasopharyngeal carcinoma, glioma and glioblastoma, non–small cell lung cancer, cholangiocarcinoma, cervical cancer, colorectal cancer, and ovarian carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, LINC01503 acts via multiple pathways to promote tumorigenesis. In several tumor models, its transcription is activated by oncogenic transcription factors such as TP63, early growth response protein 1 (EGR1), androgen receptor, c‐MYC, and GATA1, leading to high levels of LINC01503 that correlate with aggressive clinical features and poor patient outcomes (1,3,10,11). Functionally, LINC01503 enhances cancer cell proliferation, colony formation, migration, invasion, and in vivo tumor growth. In many contexts, it operates as a competing endogenous RNA (ceRNA) by “sponging” various tumor‐suppressive microRNAs including miR‑342‑3p, miR‑133a‑5p, miR‑4492, miR‑615‑3p, and miR‑766‑5p, thereby derepressing downstream targets such as DUSP6, CDKN1A, LASP1, FXYD3, vimentin (VIM), FOXK1, and PD‑L1 that drive oncogenic signaling (2,6,8,12,13,15). In addition, LINC01503 can modulate key signaling cascades. For instance, it promotes ERK/MAPK signaling (by reducing ERK2 dephosphorylation), augments Wnt/β‑catenin pathway activity either directly or via stabilization of oncogenic proteins like GLI2, and even interferes with PI3K/AKT signaling by disrupting protein interactions (1,4,5,9,10). In nasopharyngeal carcinoma, LINC01503 recruits splicing factors (e.g., SFPQ) to activate FOSL1 transcription, whereas in glioma it supports glioblastoma stem cell properties by protecting GLI2 from proteasomal degradation (3,9).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its protumorigenic effects on proliferation, invasion, and the epithelial–mesenchymal transition, aberrant LINC01503 expression has also been implicated in resistance to chemotherapy, as demonstrated by its role in carboplatin resistance in ovarian carcinoma (11). Collectively, these findings position LINC01503 as a central regulator of multiple oncogenic processes and highlight its potential as a prognostic biomarker and therapeutic target across a range of human cancers (1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17).\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jian-Jun Xie, Yan-Yi Jiang, Yuan Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2018.02.018"}], "href": "https://doi.org/10.1053/j.gastro.2018.02.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29454790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29454790"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhonghua Ma, Xiangyu Gao, You Shuai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12922"}], "href": "https://doi.org/10.1111/cpr.12922"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33145887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33145887"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shi-Wei He, Cheng Xu, Ying-Qing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-01388-8"}], "href": "https://doi.org/10.1038/s41388-020-01388-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32661324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32661324"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "H Wang, Z-G Sheng, L-Z Dai "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01503 predicts worse prognosis in glioma and promotes tumorigenesis and progression through activation of Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201902_17119"}], "href": "https://doi.org/10.26355/eurrev_201902_17119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30840283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30840283"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jian Ding, Feng Shi, Guangdong Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-020-06215-4"}], "href": "https://doi.org/10.1007/s10620-020-06215-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32207034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32207034"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qiming Shen, Yanbin Sun, Shun Xu "}, {"type": "b", "children": [{"type": "t", "text": "LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12931-020-01464-3"}], "href": "https://doi.org/10.1186/s12931-020-01464-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32938459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32938459"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Y-K Qu, X-S Qu, G Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01503 promotes cell proliferation, invasion and EMT process in cholangio-carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201908_18526"}], "href": "https://doi.org/10.26355/eurrev_201908_18526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31378883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31378883"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xing Peng, Jinyu Gao, Chunyan Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20193371"}], "href": "https://doi.org/10.1042/BSR20193371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32432654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32432654"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Pan Wei, Jing Jiang, Ming Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2022.113009"}], "href": "https://doi.org/10.1016/j.yexcr.2022.113009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34990616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34990616"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "M-L Zhang, T-T Zhao, W-W Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C-MYC-induced upregulation of LINC01503 promotes progression of non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202011_23599"}], "href": "https://doi.org/10.26355/eurrev_202011_23599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33215429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33215429"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yao Li, Yan Zhai, Yuxuan Chen "}, {"type": "b", "children": [{"type": "t", "text": "GATA1-induced upregulation of LINC01503 promotes carboplatin resistance in ovarian carcinoma by upregulating PD-L1 via sponging miR-766-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Ovarian Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13048-021-00856-3"}], "href": "https://doi.org/10.1186/s13048-021-00856-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34425872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34425872"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yanli Guo, Pingping Sun, Wei Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA LINC01503 Promotes Gastric Cardia Adenocarcinoma Progression via miR-133a-5p/VIM Axis and EMT Process."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-020-06690-9"}], "href": "https://doi.org/10.1007/s10620-020-06690-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33200343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33200343"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jing Feng, Fang-Yuan Gao, Yan-Ying Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of LINC01503 promotes cervical cancer progression by targeting the miR-615-3p/CCND1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.54148"}], "href": "https://doi.org/10.7150/jca.54148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34149919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34149919"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shui-Rong Lu, Qin Li, Jin-Lai Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01503 promotes colorectal cancer cell proliferation and invasion by regulating miR-4492/FOXK1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2018.6775"}], "href": "https://doi.org/10.3892/etm.2018.6775"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30542444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30542444"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jingsun Wei, Xiaoxu Ge, Yang Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/4728947"}], "href": "https://doi.org/10.1155/2020/4728947"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33149738"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33149738"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hua-Jun Cai, Zhi-Cheng Zhuang, Yong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development and validation of a ferroptosis-related lncRNAs prognosis signature in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bosn J Basic Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17305/bjbms.2020.5617"}], "href": "https://doi.org/10.17305/bjbms.2020.5617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33714257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33714257"}]}]}]}