{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01504 has been implicated in several disease contexts, suggesting that its dysregulation may contribute to pathogenesis through distinct mechanisms. In nontranslocation‐related sarcomas, LINC01504 functions as a fusion partner with TRIO, leading to the formation of a truncated TRIO protein that is associated with altered transcriptomic programs governing immunity/inflammation, proliferation, and migration; this fusion event is thought to represent a secondary oncogenic process involved in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of gestational diabetes mellitus, LINC01504 was identified among the differentially expressed long non‐coding RNAs and was found to be co-expressed with CASP8. This pairing suggests that LINC01504 may play a regulatory role, potentially influencing apoptotic or inflammatory signaling pathways that contribute to disease development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, in rheumatoid arthritis, upregulated expression of LINC01504 in peripheral blood mononuclear cells has shown strong correlations with clinical indicators such as disease duration, arthrocele, and joint tenderness. These findings point to its potential utility as a biomarker for disease diagnosis and progression, further underscoring its role in modulating inflammatory and immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n While other studies in hypopharyngeal cancer and non‐small cell lung cancer have focused on comprehensive transcriptomic changes in response to therapeutic agents"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", the specific involvement of LINC01504 appears most evident in contexts related to oncogenic fusion events and immune modulation. Together, these studies highlight the diverse and context-dependent roles of LINC01504 in both oncologic and inflammatory disease processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lucile Delespaul, Tom Lesluyes, Gaëlle Pérot, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Network analysis and transcriptome profiling in peripheral blood mononuclear cells of patients with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2020.9601"}], "href": "https://doi.org/10.3892/etm.2020.9601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33456537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33456537"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ping Wu, Yaoyun Tang, Xing Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metformin Suppresses Hypopharyngeal Cancer Growth by Epigenetically Silencing Long Non-coding RNA SNHG7 in FaDu Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fphar.2019.00143"}], "href": "https://doi.org/10.3389/fphar.2019.00143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30853913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30853913"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ru Chen, Juan Wu, Chang Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic Transcriptome Analysis Reveals the Inhibitory Function of Cinnamaldehyde in Non-Small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Pharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fphar.2020.611060"}], "href": "https://doi.org/10.3389/fphar.2020.611060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33633568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33633568"}]}]}]}