{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent work exploring the landscape of somatic copy‐number alterations (SCNAs) in long non‐coding RNAs (lncRNAs) in human cancers has identified focal aberrations that selectively affect lncRNA loci without impacting neighboring protein‐coding genes (1). In this context, LINC01505 has emerged as one candidate of interest: alterations in its genomic locus suggest that it may play a role in tumor pathogenesis, potentially acting as either an oncogene or a tumor suppressor. This observation is based on the detection of focal SCNAs across a panel of 80 cancer cell lines using a custom microarray that probed more than 10,000 lncRNA genes (1). Although further functional validation is necessary, the findings provide a prioritized rationale for investigating LINC01505’s role in cancer development and metastasis."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pieter-Jan Volders, Steve Lefever, Shalina Baute, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted Genomic Screen Reveals Focal Long Non-Coding RNA Copy Number Alterations in Cancer Cell Lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Noncoding RNA (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ncrna4030021"}], "href": "https://doi.org/10.3390/ncrna4030021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30217017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30217017"}]}]}]}