{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01506 is a long non‐coding RNA whose dysregulation has been associated with multiple disease contexts, suggesting its potential as a biomarker. In lung adenocarcinoma, LINC01506 is among the panel of novel prognostic lncRNAs identified as being differentially expressed and potentially involved in lung cancer–related biological processes, thus offering promise for early diagnosis and targeted therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the setting of coronary artery disease, particularly unstable angina, LINC01506 was found to be one of the most downregulated lncRNAs in peripheral blood mononuclear cells. This downregulation highlights its potential utility as part of a diagnostic expression profile aimed at distinguishing patients with unstable angina from normal controls."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in glioblastoma multiforme, LINC01506 was incorporated into an immune-related lncRNA signature capable of effectively discriminating between distinct tumor immunophenotypes. Its expression was closely linked with levels of immune cell infiltration, suggesting that LINC01506 may be a useful biomarker for immunophenotyping and could potentially help guide immunotherapeutic strategies in this aggressive brain tumor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Abbas Salavaty, Zahra Rezvani, Ali Najafi "}, {"type": "b", "children": [{"type": "t", "text": "Survival analysis and functional annotation of long non-coding RNAs in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14458"}], "href": "https://doi.org/10.1111/jcmm.14458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31211495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31211495"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sudong Liu, Jingyuan Hou, Xiaodong Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of LncRNA expression profile and identification of functional LncRNAs associated with unstable angina."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24036"}], "href": "https://doi.org/10.1002/jcla.24036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34609019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34609019"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ming Gao, Xinzhuang Wang, Dayong Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Six-lncRNA Signature for Immunophenotype Prediction of Glioblastoma Multiforme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2020.604655"}], "href": "https://doi.org/10.3389/fgene.2020.604655"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33584801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33584801"}]}]}]}