{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01508 is a long non‐coding RNA whose dysregulation has been observed in diverse disease contexts including diabetic cataract, hepatocellular carcinoma, ovarian cancer, and HER2‐negative breast cancer (1,2,3,4). In diabetic cataract, LINC01508 is one of several aberrantly expressed lncRNAs identified in the lens epithelium, suggesting a potential role in disease pathogenesis, although its precise involvement remains to be elucidated (1). In hepatocellular carcinoma, LINC01508 appears as part of a nine‐lncRNA ferroptosis‐related prognostic signature and is implicated in modulating the tumor immune microenvironment, thereby serving as an independent predictor of patient prognosis (2). In the context of ovarian cancer, LINC01508 is notably downregulated in cisplatin‐resistant cells and tissues; functional studies demonstrate that its overexpression enhances chemosensitivity by inhibiting the Hippo-YAP pathway, indicating that LINC01508 may counteract cisplatin resistance (3). Additionally, in HER2‐negative breast cancer, elevated LINC01508 expression in residual cancer tissues post-neoadjuvant chemotherapy is significantly associated with poor prognosis, highlighting its potential as a biomarker for chemo-resistance and patient outcome (4)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoyan Han, Lei Cai, Yumeng Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated Analysis of Long Non-Coding RNA -mRNA Profile and Validation in Diabetic Cataract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Eye Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/02713683.2021.1984536"}], "href": "https://doi.org/10.1080/02713683.2021.1984536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35068271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35068271"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhijie Xu, Bi Peng, Qiuju Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a Ferroptosis-Related Nine-lncRNA Signature for Predicting Prognosis and Immune Response in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.719175"}], "href": "https://doi.org/10.3389/fimmu.2021.719175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34603293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34603293"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lan Xiao, Xiao Yan Shi, Ze Lian Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gynecol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3802/jgo.2021.32.e77"}], "href": "https://doi.org/10.3802/jgo.2021.32.e77"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34132072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34132072"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dengjie Ouyang, Juan Su, Peng Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of lncRNAs via microarray analysis for predicting HER2-negative breast cancer response to neoadjuvant chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31938376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31938376"}]}]}]}