{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC01510 plays multifaceted, context‐dependent roles in cancer. In non‐small cell lung cancer, loss of the epigenetic regulator KMT5C leads to upregulation of LINC01510, which in turn promotes MET transcription and drives resistance to multiple EGFR inhibitors. In addition, increased LINC01510 expression in NSCLC enhances cell proliferation, cell cycle progression, migration, and invasion via a miR‐339-5p/CDK14 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In papillary thyroid carcinoma, SOX2 directly activates LINC01510 transcription. Elevated levels of LINC01510 then function as a competing endogenous RNA by sponging miR-335, thereby enabling increased expression of SHH and activation of the Hedgehog pathway to promote tumor cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal cancer, LINC01510 is markedly upregulated and correlates with enhanced cell proliferation and G1-to-S phase cell cycle transition. Its positive association with MET expression renders it a potential prognostic biomarker in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, studies in renal cell carcinoma suggest a tumor suppressor role for LINC01510. Downregulation of LINC01510 in RCC is associated with poor prognosis, and its ectopic expression inhibits cell proliferation and invasion by modulating the Wnt/β-catenin signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Notably, analyses in clear cell renal cell carcinoma have also incorporated LINC01510 into prognostic and diagnostic lncRNA risk models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore that LINC01510 may function as an oncogenic driver in NSCLC, papillary thyroid carcinoma, and colorectal cancer while acting as a tumor suppressor in renal cell carcinoma. Its diverse roles in regulating key pathways such as MET, Hedgehog, and Wnt/β-catenin highlight its potential as both a prognostic biomarker and a therapeutic target in a tumor type–dependent manner.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Arpita S Pal, Alejandra Agredo, Nadia A Lanman, et al. 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