{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01511 is a long non‐coding RNA that has been implicated in cancer pathogenesis. Data from several studies indicate that aberrant expression of lncRNAs—including LINC01511—may underlie key mechanisms in tumor development. One study reported extensive profiling of lncRNAs in glioblastoma, suggesting that this class of transcripts modulates diverse cellular processes and may alter gene expression networks involved in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In another study focusing on lung adenocarcinoma with EGFR exon 19 deletion, a broad microarray analysis revealed that many lncRNAs were significantly upregulated or downregulated in this molecular subtype; such findings hint that LINC01511, as part of this group of differentially expressed transcripts, might contribute to the mechanisms underlying cancer progression and treatment response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " An additional report also supports the association of LINC01511 with oncogenic processes, further pointing to its potential role as an important regulatory element in cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these abstracts suggest that LINC01511 may function as an oncogenic factor by influencing transcriptional programs that control cell proliferation, differentiation, and survival, thus contributing to tumorigenesis in both brain and lung cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yashna Paul, Sannu Thomas, Vikas Patil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic landscape of long noncoding RNA (lncRNAs) in glioblastoma: identification of complex lncRNA regulatory networks and clinically relevant lncRNAs in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.25434"}], "href": "https://doi.org/10.18632/oncotarget.25434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30038703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30038703"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yumin Wang, Wei Chen, Jie Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA expression profiles of EGFR exon 19 deletions in lung adenocarcinoma ascertained by using microarray analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0137-y"}], "href": "https://doi.org/10.1007/s12032-014-0137-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25085781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25085781"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Z H Zhou, X G Zhou, Z W Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Integrated analysis of DNA methylation and gene expression profiles of hepatocellular carcinoma to construct miR-1180-3p relevant ceRNA regulatory network]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Gan Zang Bing Za Zhi (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn501113-20200103-00003"}], "href": "https://doi.org/10.3760/cma.j.cn501113-20200103-00003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32660176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32660176"}]}]}]}