{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01512 is a long noncoding RNA with context‐dependent functions that contribute to both oncogenic processes and immune regulation. In lung adenocarcinoma, LINC01512 is markedly upregulated in tumor tissues relative to adjacent non‐tumorous samples and is closely linked to features of aggressive disease, including lymph node metastasis, advanced TNM stage, and poor patient survival. Functional studies demonstrate that increased expression of LINC01512 promotes cancer cell migration, invasion, proliferation, colony formation, and cell cycle progression while inhibiting apoptosis, thereby accelerating tumorigenesis in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Conversely, in the context of necrotising enterocolitis, LINC01512 is significantly downregulated, a change that correlates with imbalances in the proportions of regulatory T cells (Treg) and Th17 cells. Mechanistic investigations reveal that LINC01512 upregulates SIRT1 expression, which in turn promotes the differentiation of Treg cells while suppressing Th17 cell differentiation. Moreover, melatonin induces the transcription of LINC01512 via activation of the AMPK signalling pathway, suggesting that manipulation of the AMPK/LINC01512/SIRT1 axis may offer a novel therapeutic strategy to mitigate inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings underscore a dual role for LINC01512: as an oncogenic driver in lung adenocarcinoma and as a modulator of immune cell differentiation in inflammatory conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jie Chen, Fan Zhang, Junjun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01512 Promotes the Progression and Enhances Oncogenic Ability of Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26178"}], "href": "https://doi.org/10.1002/jcb.26178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28569418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28569418"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoyan Gao, Wangkai Liu, Pingmin Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melatonin-induced lncRNA LINC01512 prevents Treg/Th17 imbalance by promoting SIRT1 expression in necrotizing enterocolitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2021.107787"}], "href": "https://doi.org/10.1016/j.intimp.2021.107787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34162151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34162151"}]}]}]}