{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "LINC01515 is an emerging long non‐coding RNA that has been implicated in multiple disease contexts. In nasopharyngeal carcinoma, LINC01515 is markedly upregulated, and its high expression is associated with a worse prognosis. Functional studies demonstrate that LINC01515 promotes cell proliferation, migration, and invasion while inhibiting apoptosis by acting as a competitive endogenous RNA that sequesters miR‑325, thereby upregulating CDCA5 expression, which contributes to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "Additionally, a genome‑wide association study has identified a variant in LINC01515 that correlates with elevated cerebrospinal fluid α‑synuclein levels, suggesting a potential role for LINC01515 in the pathogenesis of neurodegenerative conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "Moreover, in the context of leukemia, particularly in doxorubicin‑resistant K562/ADR cells, LINC01515 appears to mediate drug resistance. Knockdown of LINC01515 enhances cell sensitivity to doxorubicin, an effect that is associated with disruptions in a ceRNA network involving miR‑425‑5p and DICER1, underscoring its potential as a therapeutic target for overcoming chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "Collectively, these findings elucidate the multifaceted roles of LINC01515 in cancer progression, neurodegeneration, and drug resistance, positioning it as a promising prognostic biomarker and therapeutic target."}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dan Liu, Hao Gong, Zezhang Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Histol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10735-021-09969-x"}], "href": "https://doi.org/10.1007/s10735-021-09969-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33770322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33770322"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiao-Ling Zhong, Jie-Qiong Li, Li Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Genome-Wide Association Study of α-Synuclein Levels in Cerebrospinal Fluid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurotox Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12640-018-9922-2"}], "href": "https://doi.org/10.1007/s12640-018-9922-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29959729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29959729"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhaoping Liu, Yanyan Wang, Zhenru Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of ceRNA networks and identification of potential drug targets for drug-resistant leukemia cell K562/ADR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.11429"}], "href": "https://doi.org/10.7717/peerj.11429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34113488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34113488"}]}]}]}