{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>LINC01517 Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Research into hepatocellular carcinoma has identified an 11‐lncRNA prognostic signature in which LINC01517 plays a role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In particular, LINC01517 has been incorporated into a competitive endogenous RNA (ceRNA) network where it is predicted to interact with several microRNAs. Through these interactions, it appears to modulate the expression of E2F2—a gene found to be upregulated and linked to overall prognosis in patients with HCC. Elevated risk scores, which include higher expression of LINC01517 and three other lncRNAs, are associated with poorer clinical outcomes. Although the second abstract does not provide additional specific details, the available evidence suggests that LINC01517 contributes to the regulatory circuitry underlying hepatocellular carcinoma progression and may serve as a potential prognostic indicator.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anmei Wang, Junhua Lei "}, {"type": "b", "children": [{"type": "t", "text": "Identification of an 11-lncRNA signature with high performance for predicting the prognosis of hepatocellular carcinoma using bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000023749"}], "href": "https://doi.org/10.1097/MD.0000000000023749"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33592832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33592832"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wang Li, Qi-Feng Chen, Tao Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Validation of a Prognostic lncRNA Signature for Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.00780"}], "href": "https://doi.org/10.3389/fonc.2020.00780"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32587825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32587825"}]}]}]}