{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01518 is a long noncoding RNA that has been implicated in diverse pathological processes by modulating key regulatory networks. In esophageal squamous cell carcinoma (ESCC), LINC01518 is upregulated and functions as a competing endogenous RNA (ceRNA) by binding and sequestering miR-1-3p. This interaction relieves the miR-1-3p–mediated suppression of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA), thereby activating the downstream Akt signaling pathway, which promotes cell proliferation and inhibits apoptosis. Consequently, knockdown of LINC01518 enhances miR-1-3p levels, suppresses the PIK3CA/Akt pathway, reduces cell proliferation, and induces apoptosis in ESCC cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a distinct pathological context related to human glaucoma, LINC01518 is also upregulated in human Tenon capsule fibroblast cells following TGF-β1 treatment. Its expression supports TGF-β1–induced cell proliferation, migration, and activation of the autophagy signaling pathway. Mechanistically, LINC01518 acts as a ceRNA for hsa-miR-216b-5p, and knockdown of LINC01518 results in increased levels of this miRNA, which in turn reverses the TGF-β1–induced cellular responses. This finding highlights the role of the LINC01518/hsa-miR-216b-5p axis in the regulation of cellular behaviors associated with the development of glaucoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies illustrate that LINC01518 plays a pivotal role in modulating key signaling pathways in both tumorigenesis and fibrosis-related cellular remodeling. Targeting the epigenetic axes involving LINC01518 and its associated miRNAs may offer promising therapeutic strategies for diseases such as ESCC and glaucoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Donghong Zhang, Haifeng Zhang, Xiaolong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01518 knockdown inhibits tumorigenicity by suppression of PIK3CA/Akt pathway in oesophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1699815"}], "href": "https://doi.org/10.1080/21691401.2019.1699815"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31810385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31810385"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ning Kong, YaLi Bao, Haixia Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC01518 Modulates Proliferation and Migration in TGF-β1-Treated Human Tenon Capsule Fibroblast Cells Through the Regulation of hsa-miR-216b-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromolecular Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12017-021-08662-2"}], "href": "https://doi.org/10.1007/s12017-021-08662-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33993456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33993456"}]}]}]}