{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent genetic studies are beginning to shed light on the role of long non‐coding RNAs such as LINC01522 in complex human disorders. In one study of military trauma survivors, a genome‐wide association analysis of subcortical brain volumes revealed that genetic variants, including those in high linkage disequilibrium with rs9373240, map to regions containing LINC01522. These findings suggest that LINC01522 may help regulate gene expression pathways involved in neuronal development and plasticity, thereby influencing brain structure in individuals at risk for posttraumatic stress disorder."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a complementary study examining genetic susceptibility to end‐stage kidney disease in African Americans with type 2 diabetes, several genome‐wide significant loci were identified. Although this investigation did not directly implicate LINC01522, the contrasting genetic architectures underscore the possibility that non‐coding RNAs like LINC01522 might exhibit tissue‐ or context‐specific roles. In this scenario, while LINC01522 appears to be functionally relevant to neural phenotypes that govern stress-related brain morphology"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", its involvement in other organ systems such as the kidney remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, these findings highlight LINC01522 as a candidate regulatory element in modulating genetic risk for neuropsychiatric outcomes following trauma, and they emphasize the need for further research to clarify its role across different disease contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rajendra A Morey, Sarah L Davis, Melanie E Garrett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-017-0021-6"}], "href": "https://doi.org/10.1038/s41398-017-0021-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29187748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29187748"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Meijian Guan, Jacob M Keaton, Latchezar Dimitrov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40246-019-0205-7"}], "href": "https://doi.org/10.1186/s40246-019-0205-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31092297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31092297"}]}]}]}