{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01524 is a long non‐coding RNA that has been implicated in multiple human diseases. In prostate adenocarcinoma, LINC01524 was identified as one of six lncRNAs that serve as independent prognostic factors; its differential expression correlates with overall patient survival, and analysis of its co‐expressed genes pointed to enrichment in pathways related to sensory perception (specifically olfaction and gustation). Although its precise oncogenic mechanism remains to be fully elucidated, these findings suggest that LINC01524 may be an informative biomarker and potential therapeutic target in prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genetic studies in sporadic Parkinson’s disease have revealed that single nucleotide polymorphisms affecting the LINC01524/LOC105372666 locus are associated with altered disease risk. This observation implies that LINC01524 might play a regulatory role in the pathogenesis of neurodegenerative disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n While details on LINC01524’s function in other cancers (such as those studied in abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "remain less defined, the cumulative evidence across these studies supports an emerging role for LINC01524 in cancer prognosis as well as in neurodegeneration. Further research is warranted to clarify its mechanistic contributions and to assess its utility as a clinical biomarker.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hang Huang, Yufan Tang, Xueting Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The influence of lncRNAs on the prognosis of prostate cancer based on TCGA database."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Androl Urol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tau-21-154"}], "href": "https://doi.org/10.21037/tau-21-154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33850764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33850764"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bo Wang, Xin Liu, Shengyuan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sporadic Parkinson's Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Aging Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnagi.2020.603793"}], "href": "https://doi.org/10.3389/fnagi.2020.603793"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33510632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33510632"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aining Chu, Jingwei Liu, Yuan Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of Aberrantly Expressed ceRNA network in gastric cancer with and without "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "H.pylori"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.27803"}], "href": "https://doi.org/10.7150/jca.27803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30854091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30854091"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiahong Xie, Pingshan Yang, Hongjian Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of a prognostic nomogram based on an eight-gene signature for esophageal squamous cell carcinoma by weighted gene co-expression network analysis (WGCNA)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Transl Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/atm-21-6935"}], "href": "https://doi.org/10.21037/atm-21-6935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35282133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35282133"}]}]}]}