{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although neither of the two abstracts provides a detailed, standalone account of LINC01525, the overall context of these studies allows for an informed, albeit indirect, inference regarding its potential function. In one investigation focusing on tongue squamous cell carcinoma (SCC), a series of deregulated long non‐coding RNAs (lncRNAs) were identified, whose altered expression was associated with tumor stage, nodal status, and chemoresistance (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " While LINC01525 was not specifically enumerated among the candidates (the study instead reported on lncRNAs such as lnc-MBL2-4:3 and lnc-AL355149.1-1), the broader implications of these findings support the idea that dysregulated lncRNAs can modulate key oncogenic processes.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n A second abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "further underscores the relevance of lncRNAs in tumor biology, hinting that aberrant expression of such transcripts may influence cellular pathways related to tumor progression and chemotherapeutic response. Extrapolating from these studies, it is plausible to hypothesize that LINC01525—by analogy to other cancer-associated lncRNAs—might participate in the regulation of gene expression networks that underlie malignant transformation, metastasis, and drug resistance. However, definitive functional characterization of LINC01525 remains to be established through further targeted investigations.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Gao, Jimmy Yu-Wai Chan, Thian-Sze Wong "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA deregulation in tongue squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/405860"}], "href": "https://doi.org/10.1155/2014/405860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25045670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25045670"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Opeyemi Soremekun, Chisom Soremekun, Tafadzwa Machipisa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.749415"}], "href": "https://doi.org/10.3389/fgene.2021.749415"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34925446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34925446"}]}]}]}