{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent integrative analyses of long non‐coding RNAs (lncRNAs) in diverse malignancies have underscored their potential roles as biomarkers and functional mediators in tumor progression. In tongue squamous cell carcinoma, for example, differential expression of several lncRNAs correlates with tumor stage and nodal status, highlighting the broad importance of lncRNA deregulation in cancer pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in osteosarcoma, a risk assessment model incorporating a panel of nine prognostic lncRNAs demonstrated notable accuracy in predicting patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Among the prognostically relevant lncRNAs identified in these studies, LINC01526 emerged in a comprehensive evaluation of gastric cancer patients. It was included in a thirteen‐lncRNA signature that reliably stratified patients by disease‐free survival risk, with the prognostic potency of this panel remaining independent of other clinical factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Although the functional mechanisms of LINC01526 in tumorigenesis require further exploration, its integration into a robust prognostic model suggests that aberrant expression of LINC01526 may play a contributory role in gastric cancer progression and could serve as a noninvasive biomarker for tailoring individual treatment strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Gao, Jimmy Yu-Wai Chan, Thian-Sze Wong "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA deregulation in tongue squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/405860"}], "href": "https://doi.org/10.1155/2014/405860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25045670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25045670"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kai Sun, Jianmin Zhao "}, {"type": "b", "children": [{"type": "t", "text": "A risk assessment model for the prognosis of osteosarcoma utilizing differentially expressed lncRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9768"}], "href": "https://doi.org/10.3892/mmr.2018.9768"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30569146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30569146"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Canchang Cheng, Qicai Wang, Minggu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis reveals potential long non-coding RNA biomarkers and their potential biological functions for disease free survival in gastric cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-0846-6"}], "href": "https://doi.org/10.1186/s12935-019-0846-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31080364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31080364"}]}]}]}